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J B Furness Selected Research

CP 424391

5/2015A ghrelin receptor agonist is an effective colokinetic in rats with diet-induced constipation.
2/2015Pharmacokinetics of the ghrelin agonist capromorelin in a single ascending dose Phase-I safety trial in spinal cord-injured and able-bodied volunteers.
10/2011Stimulation of defecation in spinal cord-injured rats by a centrally acting ghrelin receptor agonist.

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J B Furness Research Topics

Disease

5Constipation
12/2015 - 01/2009
2Parkinson Disease (Parkinson's Disease)
01/2016 - 12/2015
2Spinal Cord Injuries (Spinal Cord Injury)
02/2015 - 10/2011
2Intestinal Pseudo-Obstruction (Intestinal Pseudoobstruction)
08/2014 - 11/2011
2Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
10/2010 - 10/2001
2Inflammation (Inflammations)
08/2009 - 01/2008
2Megacolon
09/2008 - 10/2007
2Pain (Aches)
07/2007 - 12/2001
1Fatty Liver
08/2014
1Gastroparesis
02/2014
1Ileus
04/2012
1Infections
04/2012
1Hypersensitivity (Allergy)
02/2010
1Ganglion Cysts (Ganglion)
08/2008
1Fibrosis (Cirrhosis)
06/2007
1X-Linked Mental Retardation (Mental Retardation, X Linked)
01/2004
1Urinary Incontinence
10/2001
1Weight Loss (Weight Reduction)
09/2001

Drug/Important Bio-Agent (IBA)

4Ghrelin ReceptorsIBA
12/2015 - 01/2009
3CP 424391IBA
05/2015 - 10/2011
1copper (II) diacetyl- di(N(4)- methylthiosemicarbazone)IBA
01/2016
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
01/2016
1HM01IBA
12/2015
1GhrelinIBA
05/2015
1CholesterolIBA
08/2014
1ulimorelinIBA
02/2014
1Opioid Analgesics (Opioids)IBA
04/2012
1Prion ProteinsIBA
04/2012
1Nitric Oxide Synthase (NO Synthase)IBA
11/2011
1salicylhydroxamic acid (SHAM)IBA
10/2011
1Pregabalin (Lyrica)FDA Link
10/2010
12- amino- 4- (4- fluoronaphth- 1- yl)- 6- isopropylpyrimidineIBA
02/2010
1Serotonin (5 Hydroxytryptamine)IBA
02/2010
1Sulfonic AcidsIBA
02/2010
1Cyclic Nucleotide-Gated Cation ChannelsIBA
08/2009
1Buprenorphine (Subutex)FDA LinkGeneric
08/2009
1Proteins (Proteins, Gene)FDA Link
08/2009
1Opioid Receptors (Opioid Receptor)IBA
08/2009
1GAP-43 Protein (GAP 43 Protein)IBA
09/2008
1Potassium Channels (Potassium Channel)IBA
08/2008
1Tachykinin Receptors (Tachykinin Receptor)IBA
01/2008
1TachykininsIBA
01/2008
1NeuropeptidesIBA
10/2007
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
07/2007
1ParaffinIBA
06/2007
1rho GTPase-activating proteinIBA
01/2004
1Capsaicin (Zostrix)FDA Link
12/2001
1TAK 637IBA
10/2001
1LeptinIBA
09/2001

Therapy/Procedure

2Oral Administration
02/2010 - 01/2009
1Therapeutics
01/2016
1Truncal Vagotomy
09/2001